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Article

Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice.

Biological chemistry - 1 Jul 2006

Sevenich Lisa, Pennacchio Len A, Peters Christoph, Reinheckel Thomas

Abstract excerpt

Cathepsin B (CTSB) and cathepsin L (CTSL) are two widely expressed cysteine proteases thought to predominantly reside within lysosomes. Functional analysis of CTSL in humans is complicated by the existence of two CTSL-like homologs (CTSL and CTSL2), in contrast to mice, which possess only one CTSL enzyme. Thus, transgenic expression of human CTSL in CTSL-deficient mice provides an opportunity to study the in vivo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16913838
DOI: 10.1515/BC.2006.112

Genes

CTSL
CTSB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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