Article
Rescue of SP-B knockout mice with a truncated SP-B proprotein. Function of the C-terminal propeptide.
The Journal of biological chemistry - 11 Apr 1997
Akinbi H T, Breslin J S, Ikegami M, Iwamoto H S, Clark J C, Whitsett J A, Jobe A H, Weaver T E
Abstract excerpt
The function of the 102-amino acid C-terminal propeptide of surfactant protein B (SP-B) was analyzed by characterizing the phenotype associated with loss of expression of this peptide domain in transgenic mice. A construct encoding the signal peptide, N-terminal propeptide, and mature peptide of human SP-B (hSP-BDeltac) was cloned under the control of the 3.7-kilobase human SP-C promoter and injected into...
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