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Article

The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling.

Journal of cell science - 1 Aug 2005

Reinheckel Thomas, Hagemann Sascha, Dollwet-Mack Susanne, Martinez Elke, Lohmüller Tobias, Zlatkovic Gordana, Tobin Desmond J, Maas-Szabowski Nicole, Peters Christoph

Abstract excerpt

Mice deficient for cathepsin L (CTSL) show epidermal hyperplasia due to a hyperproliferation of basal keratinocytes. Here we show that the critical function of CTSL in the skin is keratinocyte specific. This is revealed by transgenic re-expression of CTSL in the keratinocytes of ctsl-/- mice, res...

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Source

Identifiers

PMID: 16079282
DOI: 10.1242/jcs.02469

Genes

CTSL
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16079282-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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