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Article

CGG-repeat dynamics and FMR1 gene silencing in fragile X syndrome stem cells and stem cell-derived neurons.

Molecular autism - 1 Jan 2016

Zhou Yifan, Kumari Daman, Sciascia Nicholas, Usdin Karen

Abstract excerpt

BACKGROUND: Fragile X syndrome (FXS), a common cause of intellectual disability and autism, results from the expansion of a CGG-repeat tract in the 5' untranslated region of the FMR1 gene to >200 repeats. Such expanded alleles, known as full mutation (FM) alleles, are epigenetically silenced in differentiated cells thus resulting in the loss of FMRP, a protein important for learning and memory. The timing of...

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Share to 5' Untranslated Regions
Share to Embryonic Stem Cells
Share to Fragile X Mental Retardation Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fragile X Syndrome

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Share to Induced Pluripotent Stem Cells

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Source

Open in PubMed Open full text

Identifiers

PMID: 27713816
DOI: 10.1186/s13229-016-0105-9
PMCID: PMC5053128

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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