Article
Effects of the C-terminal truncation in NS1 protein of the 2009 pandemic H1N1 influenza virus on host gene expression.
PloS one - 1 Jan 2011
Tu Jiagang, Guo Jing, Zhang Anding, Zhang Wenting, Zhao Zongzheng, Zhou Hongbo, Liu Cheng, Chen Huanchun, Jin Meilin
Abstract excerpt
The 2009 pandemic H1N1 influenza virus encodes an NS1 protein with 11 amino acids (aa) truncation at the C-terminus. The C-terminal tail of influenza virus NS1 protein constitutes a nucleolar localization signal (NoLS) and is the binding domain of the cellular pre-mRNA processing protein, poly(A)-binding protein II (PABII). Here, our studies showed that the C-terminal-truncated NS1 of the 2009 pandemic virus was...
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