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Article

Role of N Terminus-Truncated NS1 Proteins of Influenza A Virus in Inhibiting IRF3 Activation.

Journal of virology - 1 May 2016

Kuo Rei-Lin, Li Li-Hsin, Lin Sue-Jane, Li Zong-Hua, Chen Guang-Wu, Chang Cheng-Kai, Wang Yi-Ren, Tam Ee-Hong, Gong Yu-Nong, Krug Robert M, Shih Shin-Ru

Abstract excerpt

UNLABELLED: The NS1 protein encoded by influenza A virus antagonizes the interferon response through various mechanisms, including blocking cellular mRNA maturation by binding the cellular CPSF30 3' end processing factor and/or suppressing the activation of interferon regulatory factor 3 (IRF3). In the present study, we identified two truncated NS1 proteins that are translated from internal AUGs at positions 235...

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Source

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Identifiers

PMID: 26912617
DOI: 10.1128/JVI.02843-15
PMCID: PMC4836362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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