Article
The role of nuclear NS1 protein in highly pathogenic H5N1 influenza viruses.
Microbes and infection - 1 Dec 2017
Mok Bobo Wing-Yee, Liu Honglian, Chen Pin, Liu Siwen, Lau Siu-Ying, Huang Xiaofeng, Liu Yen-Chin, Wang Pui, Yuen Kwok-Yung, Chen Honglin
Abstract excerpt
The non-structural protein (NS1) of influenza A viruses (IAV) performs multiple functions during viral infection. NS1 contains two nuclear localization signals (NLS): NLS1 and NLS2. The NS1 protein is located predominantly in the nucleus during the early stages of infection and subsequently exported to the cytoplasm. A nonsense mutation that results in a large deletion in the carboxy-terminal region of the NS1...
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