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Specificity and functional interplay between influenza virus PA-X and NS1 shutoff activity

29 Nov 2018

Abstract excerpt

Influenza A viruses modulate host antiviral responses to promote viral growth and pathogenicity. Through viral PA-X and NS1 proteins, the virus is capable of suppressing host protein synthesis, termed "host shutoff." Although both proteins are known to induce general shutoff, specificity of target genes and their functional interplay in mediating host shutoff are not fully elucidated. In this study, we generated...

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Influenza Virus Research Studies
interferon and immune responses
Respiratory viral infections research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30496325
DOI: 10.1371/journal.ppat.1007465

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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