Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Critical Role of the PA-X C-Terminal Domain of Influenza A Virus in Its Subcellular Localization and Shutoff Activity.

Journal of virology - 15 Aug 2016

Hayashi Tsuyoshi, Chaimayo Chutikarn, McGuinness James, Takimoto Toru

Abstract excerpt

UNLABELLED: PA-X is a recently identified influenza virus protein that is composed of the PA N-terminal 191 amino acids and unique C-terminal 41 or 61 residues. We and others showed that PA-X has a strong ability to suppress host protein synthesis via host mRNA decay, which is mediated by endonuclease activity in its N-terminal domain (B. W. Jagger, H. M. Wise, J. C. Kash, K. A. Walters, N. M. Wills, Y. L. Xiao,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to A549 Cells
Share to Blotting, Northern
Share to Host-Pathogen Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza A virus

Share to Influenza, Human

Share to RNA Stability

Share to Subcellular Fractions

Share to Viral Nonstructural Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 27226377
DOI: 10.1128/JVI.00954-16
PMCID: PMC4984632

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Critical Role of the PA-X C-Terminal Domain of Influenza A Virus in Its Subcellular Localization and Shutoff Activity.PMID 27226377Read ↗

Influenza A virus NS1 effector domain is required for PA-X-mediated host shutoff in infected cellsSemantic proximity Read ↗

N-terminal acetylation controls multiple functional aspects of the influenza A virus ribonuclease PA-XSemantic proximity Read ↗

Influenza A virus NS1 effector domain is required for PA-X mediated host shutoffSemantic proximity Read ↗

Specificity and functional interplay between influenza virus PA-X and NS1 shutoff activitySemantic proximity Read ↗

Influenza A Virus Protein PA-X Contributes to Viral Growth and Suppression of the Host Antiviral and Immune ResponsesSemantic proximity Read ↗

An overlapping protein-coding region in influenza A virus segment 3 modulates the host response.Semantic proximity Read ↗

Twenty amino acids at the C-terminus of PA-X are associated with increased influenza A virus replication and pathogenicitySemantic proximity Read ↗

The PA-X host shutoff site 100 V exerts a contrary effect on viral fitness of the highly pathogenic H7N9 influenza A virus in mice and chickensSemantic proximity Read ↗

Comparing the functions of equine and canine influenza H3N8 virus PA-X proteins: Suppression of reporter gene expression and modulation of global host gene expression.Semantic proximity Read ↗

PA-X: a key regulator of influenza A virus pathogenicity and host immune responsesSemantic proximity Read ↗

The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza virusesSemantic proximity Read ↗

Impacts of different expressions of PA-X protein on 2009 pandemic H1N1 virus replication, pathogenicity and host immune responses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.