Article

Influenza A virus NS1 effector domain is required for PA-X mediated host shutoff

2023-10-04

Abstract excerpt

<h4>ABSTRACT</h4> Many viruses inhibit general host gene expression to limit innate immune responses and gain preferential access to the cellular translational apparatus for their own protein synthesis. This process is known as host shutoff. Influenza A viruses (IAVs) encode two host shutoff proteins: nonstructural protein 1 (NS1) and polymerase acidic X (PA-X). NS1 inhibits host nuclear pre-messenger RNA maturat...

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Literature Corpus work: a41265c4-5076-5e64-93b0-5c61853c6ab8
DOI: 10.1101/2023.10.02.560421

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