Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of Soat1 as a quantitative trait locus gene on mouse chromosome 1 contributing to hyperlipidemia.

PloS one - 1 Jan 2011

Lu Zongji, Yuan Zuobiao, Miyoshi Toru, Wang Qian, Su Zhiguang, Chang Catherine C, Shi Weibin

Abstract excerpt

We previously identified two closely linked quantitative trait loci (QTL) on distal chromosome 1 contributing to major variations in plasma cholesterol and triglyceride levels in an intercross derived from C57BL/6 (B6) and C3H/HeJ (C3H) apolipoprotein E-deficient (apoE(-/-)) mice. Soat1, encoding sterol o-acyltransferase 1, is a functional candidate gene located underneath the proximal linkage peak. We sequenced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoproteins E
Share to Cholesterol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Mammalian

Share to Hyperlipidemias

Share to Lipids

Share to Lod Score

Share to Macrophages, Peritoneal

Share to Mice, Inbred C3H

Source

Open in PubMed Open full text

Identifiers

PMID: 22022387
DOI: 10.1371/journal.pone.0025344
PMCID: PMC3194806

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of Soat1 as a quantitative trait locus gene on mouse chromosome 1 contributing to hyperlipidemia.PMID 22022387Read ↗

Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice.Semantic proximity Read ↗

Acyl-Coenzyme A: Cholesterol Acyltransferase (ACAT) in Cholesterol Metabolism: From Its Discovery to Clinical Trials and the Genomics EraSemantic proximity Read ↗

Tachol1 QTL on mouse chromosome 1 is responsible for hypercholesterolemia and diet-induced obesity.Semantic proximity Read ↗

Quantitative Trait Locus Mapping of Macrophage Cholesterol Metabolism and CRISPR/Cas9 Editing Implicate an ACAT1 Truncation as a Causal Modifier Variant.Semantic proximity Read ↗

QTL-mapping in the obese Berlin Fat Mouse identifies additional candidate genes for obesity and fatty liver diseaseSemantic proximity Read ↗

A Novel Mapping Strategy Utilizing Mouse Chromosome Substitution Strains Identifies Multiple Epistatic Interactions That Regulate Complex Traits.Semantic proximity Read ↗

Functional Characterization of Lipid Regulatory Effects of Three Genes Using Knockout Mouse ModelsSemantic proximity Read ↗

A functional variant of the <i>SIDT2</i> gene involved in cholesterol transport is associated with HDL-C levels and premature coronary artery diseaseSemantic proximity Read ↗

High-resolution genetic mapping in the diversity outbred mouse population identifies Apobec1 as a candidate gene for atherosclerosis.Semantic proximity Read ↗

Genetic determinants of atherosclerosis, obesity, and energy balance in consomic mice.Semantic proximity Read ↗

Genetic, epigenetic, and gene-by-diet interaction effects underlie variation in serum lipids in a LG/JxSM/J murine model.Semantic proximity Read ↗

Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.