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Article

Beyond translesion synthesis: polymerase κ fidelity as a potential determinant of microsatellite stability.

Nucleic acids research - 1 Feb 2012

Hile Suzanne E, Wang Xiaoxiao, Lee Marietta Y W T, Eckert Kristin A

Abstract excerpt

Microsatellite DNA synthesis represents a significant component of human genome replication that must occur faithfully. However, yeast replicative DNA polymerases do not possess high fidelity for microsatellite synthesis. We hypothesized that the structural features of Y-family polymerases that facilitate accurate translesion synthesis may promote accurate microsatellite synthesis. We compared human polymerases κ...

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Identifiers

PMID: 22021378
DOI: 10.1093/nar/gkr889
PMCID: PMC3287198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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