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Article

Mutation of the little finger domain in human DNA polymerase η alters fidelity when copying undamaged DNA.

Environmental and molecular mutagenesis - 1 Oct 2013

Beardslee Renee A, Suarez Samuel C, Toffton Shannon M, McCulloch Scott D

Abstract excerpt

DNA polymerase η (pol η) synthesizes past cyclobutane pyrimidine dimer and possibly 7,8-dihydro-8-oxoguanine (8-oxoG) lesions during DNA replication. Loss of pol η is associated with an increase in mutation rate, demonstrating its indispensable role in mutation suppression. It has been recently reported that β-strand 12 (amino acids 316-324) of the little finger region correctly positions the template strand with...

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Identifiers

PMID: 23913529
DOI: 10.1002/em.21807
PMCID: PMC4120640

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Source receipt: pubmed, retrieved 7 Sept 2026.

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