A unique error signature for human DNA polymerase nu.

doi:10.1016/j.dnarep.2006.09.012

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Article

A unique error signature for human DNA polymerase nu.

DNA repair - 4 Feb 2007

Arana Mercedes E, Takata Kei-ichi, Garcia-Diaz Miguel, Wood Richard D, Kunkel Thomas A

Abstract excerpt

Human DNA polymerase nu (pol nu) is one of three A family polymerases conserved in vertebrates. Although its biological functions are unknown, pol nu has been implicated in DNA repair and in translesion DNA synthesis (TLS). Pol nu lacks intrinsic exonucleolytic proofreading activity and discriminates poorly against misinsertion of dNTP opposite template thymine or guanine, implying that it should copy DNA with...

Topics

Amino Acid Sequence
Base Pairing
Base Sequence
Catalytic Domain
DNA
DNA Repair
DNA-Directed DNA Polymerase
Genetic Complementation Test
Humans
In Vitro Techniques
Models, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Protein Conformation

Recombinant Proteins

Sequence Homology, Amino Acid

Substrate Specificity

Source

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Identifiers

PMID: 17118716
DOI: 10.1016/j.dnarep.2006.09.012
PMCID: PMC1950682

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