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Article

Human globin locus activation region (LAR): role in temporal control.

Trends in genetics : TIG - 1 Jul 1990

Townes T M, Behringer R R

Abstract excerpt

A region of DNA located far upstream of the human beta-globin locus is critically involved in the regulation of the beta-globin gene family. Recent experiments in transgenic mice suggest that switching from fetal to adult globin gene expression during human development results from competition among individual globin gene family members for interaction with sequences in this region. The phenotypes of patients...

Topics

Animals
Gene Expression Regulation
Globins
Humans
Mice
Mice, Transgenic
Multigene Family
Phenotype

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2202110
DOI: 10.1016/0168-9525(90)90182-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2202110-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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