Article

Reactivation of developmentally silenced globin genes through genomic deletions reveals that enhancer distance matters

2025-01-15

Abstract excerpt

The human genome contains regulatory DNA elements, enhancers, that can activate gene transcription over long chromosomal distances. Here, we show that enhancer distance can be critical for gene silencing. We demonstrate that linear recruitment of the normally distal HBB super-enhancer to developmentally silenced HBG promoters, through deletion or inversion of intervening DNA sequences, results in strongly reacti...

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Literature Corpus work: a7e642f1-5b57-5a5d-b99e-98be2c1471ab
DOI: 10.1101/2025.01.13.632719

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