Article
Coordinate stabilization of growth-regulatory transcripts in T cell malignancies.
Genomics - 1 Aug 2005
Vlasova Irina A, McNabb Jennifer, Raghavan Arvind, Reilly Cavan, Williams Darlisha A, Bohjanen Kimberly A, Bohjanen Paul R
Abstract excerpt
We used microarray technology to compare mRNA decay rates of approximately 7000 transcripts in normal purified human T lymphocytes or the malignant T cell lines Jurkat and H9 following transcriptional arrest with actinomycin D. We found that over 2000 transcripts were expressed at abnormal levels in malignant T cells, including approximately 100 transcripts that were overexpressed and exhibited abnormally stable...
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