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Article

Evolutionary gamut of in vivo Gag substitutions during early HIV-1 subtype C infection.

Virology - 20 Dec 2011

Novitsky Vladimir, Wang Rui, Baca Jeannie, Margolin Lauren, McLane Mary F, Moyo Sikhulile, van Widenfelt Erik, Makhema Joseph, Essex M

Abstract excerpt

Two analyses of HIV-1 subtype C Gag quasispecies were performed in a prospective cohort of 42 acutely and recently infected individuals by SGA on viral RNA/proviral DNA templates. First, in vivo Gag substitutions were assessed in relation to the HIV-1C consensus sequence, which revealed that 29.3% of detected amino acid substitutions can be classified as reversions to subtype consensus, 61.3% as forward...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22014506
DOI: 10.1016/j.virol.2011.09.020
PMCID: PMC3210886

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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