Article
Timing constraints of in vivo gag mutations during primary HIV-1 subtype C infection.
PloS one - 5 Nov 2009
Novitsky Vladimir, Wang Rui, Margolin Lauren, Baca Jeannie, Kebaabetswe Lemme, Rossenkhan Raabya, Bonney Caitlin, Herzig Michaela, Nkwe David, Moyo Sikhulile, Musonda Rosemary, Woldegabriel Elias, van Widenfelt Erik, Makhema Joseph, Lagakos Stephen, Essex M
Abstract excerpt
BACKGROUND: Aiming to answer the broad question "When does mutation occur?" this study examined the time of appearance, dominance, and completeness of in vivo Gag mutations in primary HIV-1 subtype C infection. METHODS: A primary HIV-1C infection cohort comprised of 8 acutely and 34 recently infected subjects were followed frequently up to 500 days post-seroconversion (p/s). Gag mutations were analyzed by...
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