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Article

Involvement of a Rarely Used Splicing SD2b Site in the Regulation of HIV-1 vif mRNA Production as Revealed by a Growth-Adaptive Mutation.

Viruses - 14 Dec 2023

Koma Takaaki, Doi Naoya, Le Bao Quoc, Kondo Tomoyuki, Ishizue Mitsuki, Tokaji Chiaki, Tsukada Chizuko, Adachi Akio, Nomaguchi Masako

Abstract excerpt

We have previously reported an HIV-1 mutant designated NL-Y226tac that expresses Vif at an ultra-low level, being replication-defective in high-APOBEC3G cells, such as H9. It carries a synonymous mutation within the splicing SA1 site relative to its parental clone. In order to determine whether a certain mutant(s) emerges during multi-infection cycles, we maintained H9 cells infected with a relatively low or high...

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Identifiers

PMID: 38140666
DOI: 10.3390/v15122424
PMCID: PMC10747208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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