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Article

The discovery of GGT1 as a novel gene for ischemic stroke conferring protection against disease risk in non-smokers and non-abusers of alcohol.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Jun 2024

Solodilova Maria, Drozdova Elena, Azarova Iuliia, Klyosova Elena, Bykanova Marina, Bushueva Olga, Polonikova Anna, Churnosov Mikhail, Polonikov Alexey

Abstract excerpt

OBJECTIVES: Increased plasma gamma-glutamyl transferase (GGT1) has been identified as a robust and independent risk factor for ischemic stroke (IS), but the molecular mechanisms of the enzyme-disease association are unclear. The present study investigated whether polymorphisms in the GGT1 gene contribute to IS susceptibility. MATERIALS AND METHODS: DNA samples obtained from 1288 unrelated individuals (600 IS...

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PMID: 38522756
DOI: 10.1016/j.jstrokecerebrovasdis.2024.107685

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