Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes.

doi:10.1038/s41467-021-22338-2

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Article

Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes.

Nature communications - 10 May 2021

Pazoki Raha, Vujkovic Marijana, Elliott Joshua, Evangelou Evangelos, Gill Dipender, Ghanbari Mohsen, van der Most Peter J, Pinto Rui Climaco, Wielscher Matthias, Farlik Matthias, Zuber Verena, de Knegt Robert J, Snieder Harold, Uitterlinden André G, Lynch Julie A, Jiang Xiyun, Said Saredo, Kaplan David E, Lee Kyung Min, Serper Marina, Carr Rotonya M, Tsao Philip S, Atkinson Stephen R, Dehghan Abbas, Tzoulaki Ioanna, Ikram M Arfan, Herzig Karl-Heinz, Järvelin Marjo-Riitta, Alizadeh Behrooz Z, O'Donnell Christopher J, Saleheen Danish, Voight Benjamin F, Chang Kyong-Mi, Thursz Mark R, Elliott Paul

Abstract excerpt

Serum concentration of hepatic enzymes are linked to liver dysfunction, metabolic and cardiovascular diseases. We perform genetic analysis on serum levels of alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) using data on 437,438 UK Biobank participants. Replication in 315,572 individuals from European descent from the Million Veteran Program, Rotterdam Study and Lifeline...

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Identifiers

PMID: 33972514
DOI: 10.1038/s41467-021-22338-2
PMCID: PMC8110798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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