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Article

Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.

American journal of human genetics - 1 Oct 2008

Yuan Xin, Waterworth Dawn, Perry John R B, Lim Noha, Song Kijoung, Chambers John C, Zhang Weihua, Vollenweider Peter, Stirnadel Heide, Johnson Toby, Bergmann Sven, Beckmann Noam D, Li Yun, Ferrucci Luigi, Melzer David, Hernandez Dena, Singleton Andrew, Scott James, Elliott Paul, Waeber Gerard, Cardon Lon, Frayling Timothy M, Kooner Jaspal S, Mooser Vincent

Abstract excerpt

Plasma liver-enzyme tests are widely used in the clinic for the diagnosis of liver diseases and for monitoring the response to drug treatment. There is considerable evidence that human genetic variation influences plasma levels of liver enzymes. However, such genetic variation has not been systematically assessed. In the present study, we performed a genome-wide association study of plasma liver-enzyme levels in...

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Identifiers

PMID: 18940312
DOI: 10.1016/j.ajhg.2008.09.012
PMCID: PMC2561937

Genes

ABO
ALPL
CHUK
CPN1
ERLIN1
GGT1
GPLD1
PNPLA3
REEP3
SAMM50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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