Article
The role of oxidative stress in carcinogenesis.
Annual review of pharmacology and toxicology - 1 Jan 2004
Klaunig James E, Kamendulis Lisa M
Abstract excerpt
Chemical carcinogenesis follows a multistep process involving both mutation and increased cell proliferation. Oxidative stress can occur through overproduction of reactive oxygen and nitrogen species through either endogenous or exogenous insults. Important to carcinogenesis, the unregulated or prolonged production of cellular oxidants has been linked to mutation (induced by oxidant-induced DNA damage), as well...
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