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Article

Allele-specific interaction between glutathione peroxidase 1 and manganese superoxide dismutase affects the levels of Bcl-2, Sirt3 and E-cadherin.

Free radical research - 1 Jun 2017

Ekoue Dede N, Bera Soumen, Ansong Emmanuel, Hart Peter C, Zaichick Sofia, Domann Frederick E, Bonini Marcelo G, Diamond Alan M

Abstract excerpt

Manganese superoxide dismutase (MnSOD) is a mitochondrial-resident enzyme that reduces superoxide to hydrogen peroxide (H2O2), which can be further reduced to water by glutathione peroxidase (GPX1). Data from human studies have indicated that common polymorphisms in both of these proteins are associated with the risk of several cancers, including breast cancer. Moreover, polymorphisms in MnSOD and GPX1 were shown...

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Source

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Identifiers

PMID: 28587495
DOI: 10.1080/10715762.2017.1339303
PMCID: PMC5683088

Genes

GPX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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