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Article

In vitro acquisition of secondary azole resistance in Aspergillus fumigatus isolates after prolonged exposure to itraconazole: presence of heteroresistant populations.

Antimicrobial agents and chemotherapy - 1 Jan 2012

Escribano Pilar, Recio Sandra, Peláez Teresa, González-Rivera Milagros, Bouza Emilio, Guinea Jesús

Abstract excerpt

Secondary resistance to azoles in Aspergillus fumigatus isolates from patients taking long-term itraconazole therapy has been described. We studied the acquisition of secondary azole resistance in 20 A. fumigatus isolates with no mutations at codon 54, 98, 138, 220, 432, or 448 in the cyp51A gene. Adjusted conidium inocula (3 × 10(7) CFU/ml) of each isolate were prepared and progressively or directly exposed to...

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Identifiers

PMID: 22006000
DOI: 10.1128/AAC.00301-11
PMCID: PMC3256017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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