Article
In vivo emergence of Aspergillus terreus with reduced azole susceptibility and a Cyp51a M217I alteration.
The Journal of infectious diseases - 15 Sept 2012
Arendrup Maiken C, Jensen Rasmus H, Grif Katharina, Skov Marianne, Pressler Tacjana, Johansen Helle K, Lass-Flörl Cornelia
Abstract excerpt
Azole resistance in Aspergillus terreus isolates was explored. Twenty related (MB) and 6 unrelated A. terreus isolates were included. CYP51A sequencing and RAPD genotyping was performed. Five MB isolates were itraconazole susceptible, whereas the minimum inhibitory concentrations (MICs) for 15 MB isolates were elevated (1-2 mg/L). Voriconazole and posaconazole MICs were 0.5-4 and 0.06-0.5 mg/L, respectively, for...
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