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Article

NIK prevents the development of hypereosinophilic syndrome-like disease in mice independent of IKKα activation.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2012

Häcker Hans, Chi Liying, Rehg Jerold E, Redecke Vanessa

Abstract excerpt

Immune cell-mediated tissue injury is a common feature of different inflammatory diseases, yet the pathogenetic mechanisms and cell types involved vary significantly. Hypereosinophilic syndrome (HES) represents a group of inflammatory diseases that is characterized by increased numbers of pathogenic eosinophilic granulocytes in the peripheral blood and diverse organs. On the basis of clinical and laboratory...

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Identifiers

PMID: 22474019
DOI: 10.4049/jimmunol.1200021
PMCID: PMC3532048

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