Article
Generation and Surgical Analysis of Genetic Mouse Models to Study NF-κB-Driven Pathogenesis of Diffuse Large B Cell Lymphoma.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021
Maybury Bernard D, Saavedra-Torres Yolanda, Snoeks Thomas J A, Fitzgibbon Jude, Calado Dinis P
Abstract excerpt
Enforced activation of NF-κB signaling can be achieved by constitutive NF-κB-inducing kinases, IKK2 and NIK, or via lymphoma-associated mutants of MYD88, CARD11, and CD79B. In order to model Diffuse Large B Cell Lymphoma (DLBCL) in mice, conditional alleles for these proteins are combined with alleles targeting Cre recombinase expression in mature B cells. However, unopposed NF-κB signaling promotes plasmablast...
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