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Article

NF-κB-inducing kinase in thymic stroma establishes central tolerance by orchestrating cross-talk with not only thymocytes but also dendritic cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2014

Mouri Yasuhiro, Nishijima Hitoshi, Kawano Hiroshi, Hirota Fumiko, Sakaguchi Nobuo, Morimoto Junko, Matsumoto Mitsuru

Abstract excerpt

Essential roles of NF-κB-inducing kinase (NIK) for the development of medullary thymic epithelial cells (mTECs) and regulatory T cells have been highlighted by studies using a strain of mouse bearing a natural mutation of the NIK gene (aly mice). However, the exact mechanisms underlying the defect in thymic cross-talk leading to the breakdown of self-tolerance in aly mice remain elusive. In this study, we...

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Identifiers

PMID: 25261487
DOI: 10.4049/jimmunol.1400389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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