Article
Blinded study determination of high sensitivity and specificity microchip electrophoresis-SSCP/HA to detect mutations in the p53 gene.
Electrophoresis - 1 Nov 2011
Hestekin Christa N, Lin Jennifer S, Senderowicz Lionel, Jakupciak John P, O'Connell Catherine, Rademaker Alfred, Barron Annelise E
Abstract excerpt
Knowledge of the genetic changes that lead to disease has grown and continues to grow at a rapid pace. However, there is a need for clinical devices that can be used routinely to translate this knowledge into the treatment of patients. Use in a clinical setting requires high sensitivity and specificity (>97%) in order to prevent misdiagnoses. Single-strand conformational polymorphism (SSCP) and heteroduplex...
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