Article
Microchip electrophoresis: a method for high-speed SNP detection.
Nucleic acids research - 1 May 2000
Schmalzing D, Belenky A, Novotny M A, Koutny L, Salas-Solano O, El-Difrawy S, Adourian A, Matsudaira P, Ehrlich D
Abstract excerpt
As a trial practical application, we have applied optimized microfabricated electrophoresis devices, combined with enzymatic mutation detection methods, to the determination of single nucleotide polymorphism (SNP) sites in the p53 suppressor gene. Using clinical samples, we have achieved robust assays with quality factors as good as conventional electrophoresis in approximately 100 s. This is 10 and 50 times...
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