Article
Characterization of human immunodeficiency virus type 1 (HIV-1) diversity and tropism in 145 patients with primary HIV-1 infection.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Dec 2011
Rieder Philip, Joos Beda, Scherrer Alexandra U, Kuster Herbert, Braun Dominique, Grube Christina, Niederöst Barbara, Leemann Christine, Gianella Sara, Metzner Karin J, Böni Jürg, Weber Rainer, Günthard Huldrych F
Abstract excerpt
BACKGROUND: In the context of sexual transmission of human immunodeficiency virus type 1 (HIV-1), current findings suggest that the mucosal barrier is the major site of viral selection, transforming the complex inoculum to a small, homogeneous founder virus population. We analyzed HIV-1 transmission in relation to viral and host characteristics within the Zurich primary HIV-1 infection study. METHODS: Clonal...
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