Article
Characterization of HIV-1 diversity in various compartments at the time of primary infection by ultradeep sequencing.
Scientific reports - 12 Feb 2020
Gaube Géraldine, Armero Alix, Salmona Maud, Néré Marie-Laure, Mahjoub Nadia, Lascoux-Combe Caroline, Gabassi Audrey, Gallien Sébastien, Amara Ali, Molina Jean Michel, Delaugerre Constance, Chaix Marie-Laure
Abstract excerpt
We used next-generation sequencing to evaluate the quantity and genetic diversity of the HIV envelope gene in various compartments in eight patients with acute infection. Plasma (PL) and seminal fluid (SF) were available for all patients, whole blood (WB) for seven, non-spermatozoid cells (NSC) for four, and saliva (SAL) for three. Median HIV-1 RNA was 6.2 log10 copies/mL [IQR: 5.5-6.95] in PL, 4.9 log10...
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