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Article

Higher sequence diversity in the vaginal tract than in blood at early HIV-1 infection.

PLoS pathogens - 1 Jan 2018

Klein Katja, Nickel Gabrielle, Nankya Immaculate, Kyeyune Fred, Demers Korey, Ndashimye Emmanuel, Kwok Cynthia, Chen Pai-Lien, Rwambuya Sandra, Poon Art, Munjoma Marshall, Chipato Tsungai, Byamugisha Josaphat, Mugyenyi Peter, Salata Robert A, Morrison Charles S, Arts Eric J

Abstract excerpt

In the majority of cases, human immunodeficiency virus type 1 (HIV-1) infection is transmitted through sexual intercourse. A single founder virus in the blood of the newly infected donor emerges from a genetic bottleneck, while in rarer instances multiple viruses are responsible for systemic infection. We sought to characterize the sequence diversity at early infection, between two distinct anatomical sites; the...

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Identifiers

PMID: 29346424
DOI: 10.1371/journal.ppat.1006754
PMCID: PMC5773221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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