Predicting response to therapy in chronic hepatitis C: an approach combining interleukin-28B gene polymorphisms and clinical data.

doi:10.1111/j.1440-1746.2011.06834.x

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Article

Predicting response to therapy in chronic hepatitis C: an approach combining interleukin-28B gene polymorphisms and clinical data.

Journal of gastroenterology and hepatology - 1 Feb 2012

Ladero José M, Martin Elena García, Fernández Cristina, Carballo Miguel, Devesa María J, Martínez Carmen, Suárez Avelina, Díaz-Rubio Manuel, Agúndez José A

Abstract excerpt

BACKGROUND AND AIM: Polymorphisms at the interleukin-28B (IL28B) gene predict therapeutic response in chronic hepatitis C virus genotype 1 (CHC-1) infection. The aim of the present study was to establish whether a unique single-nucleotide polymorphism (SNP) represents the whole predictive value of the IL28B haplotype for sustained viral response (SVR) and primary non-response (PNR). METHODS: SNP rs12979860 and...

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PMID: 21722179
DOI: 10.1111/j.1440-1746.2011.06834.x

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