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SIRT7 Downregulation Promotes Breast Cancer Metastasis Via LAP2α-Induced Chromosomal Instability

1 Jan 2023

Abstract excerpt

Chromosomal instability (CIN) plays an important role in the initiation and progression of carcinomas. However, the regulatory mechanism of metastasis mediated by CIN in breast cancer is not fully understood. Here, we aimed to demonstrate that the deregulation of SIRT7 and lamina-associated polypeptide 2 (LAP2) critically contributes to CIN-induced metastasis in breast cancer. Expression of SIRT7 and chromosome...

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PMID: 37056924
DOI: 10.7150/ijbs.75340

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