Mutation of Foxo3 causes adult onset auditory neuropathy and alters cochlear synapse architecture in mice.

doi:10.1523/JNEUROSCI.2529-13.2013

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Mutation of Foxo3 causes adult onset auditory neuropathy and alters cochlear synapse architecture in mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Nov 2013

Gilels Felicia, Paquette Stephen T, Zhang Jingyuan, Rahman Irfan, White Patricia M

Abstract excerpt

Auditory neuropathy is a form of hearing loss in which cochlear inner hair cells fail to correctly encode or transmit acoustic information to the brain. Few genes have been implicated in the adult-onset form of this disease. Here we show that mice lacking the transcription factor Foxo3 have adult onset hearing loss with the hallmark characteristics of auditory neuropathy, namely, elevated auditory thresholds...

Topics

Acoustic Stimulation
Age Factors
Alcohol Oxidoreductases
Animals
Animals, Newborn
Calcium-Binding Proteins
Co-Repressor Proteins
Cochlea
DNA-Binding Proteins
Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Evoked Potentials, Auditory, Brain Stem

Forkhead Box Protein O3

Forkhead Transcription Factors

Gene Expression Regulation, Developmental

Hair Cells, Auditory, Inner

Hearing Loss, Central

Imaging, Three-Dimensional

Mice

Source

Open in PubMed Open full text

Identifiers

PMID: 24259566
DOI: 10.1523/JNEUROSCI.2529-13.2013
PMCID: PMC6618809

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation of Foxo3 causes adult onset auditory neuropathy and alters cochlear synapse architecture in mice.PMID 24259566Read ↗

Endogenous SIRT3 activity is dispensable for normal hearing recovery after noise exposure in young adult miceSemantic proximity Read ↗

Signaling in the Auditory System: Implications in Hair Cell Regeneration and Hearing Function.Semantic proximity Read ↗

A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens.Semantic proximity Read ↗

The human OPA1delTTAG mutation induces adult onset and progressive auditory neuropathy in mice.Semantic proximity Read ↗

<i>NCOA3</i> identified as a new candidate to explain autosomal dominant progressive hearing lossSemantic proximity Read ↗

NCOA3 identified as a new candidate to explain autosomal dominant progressive hearing loss.Semantic proximity Read ↗

Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human.Semantic proximity Read ↗

Knock-In Mice with Myo3a Y137C Mutation Displayed Progressive Hearing Loss and Hair Cell Degeneration in the Inner Ear.Semantic proximity Read ↗

Beyond Excitotoxicity: Glutamate-Independent Mechanisms Underlie Noise-Induced Synaptopathy and Compromise Gene Therapy for Hereditary DeafnessSemantic proximity Read ↗

Altered Fhod3 Expression Involved in Progressive High-Frequency Hearing Loss via Dysregulation of Actin Polymerization Stoichiometry in The Cuticular PlateSemantic proximity Read ↗

Defects in hair cells disrupt the development of auditory peripheral circuitry.Semantic proximity Read ↗

BDNF gene therapy induces auditory nerve survival and fiber sprouting in deaf Pou4f3 mutant mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.