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Article

GATA3 haploinsufficiency causes a rapid deterioration of distortion product otoacoustic emissions (DPOAEs) in mice.

Neurobiology of disease - 1 Dec 2005

van Looij M A J, van der Burg H, van der Giessen R S, de Ruiter M M, van der Wees J, van Doorninck J H, De Zeeuw C I, van Zanten G A

Abstract excerpt

Human HDR (hypoparathyroidism, deafness and renal dysplasia)-syndrome is caused by haploinsufficiency of zinc-finger transcription factor GATA3. The hearing loss due to GATA3 haploinsufficiency has been shown to be peripheral in origin, but it is unclear to what extent potential aberrations in the outer hair cells (OHCs) contribute to this disorder. To further elucidate the pathophysiological mechanism underlying...

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Share to Evoked Potentials, Auditory
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hair Cells, Auditory, Outer

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Source

Identifiers

PMID: 15994092
DOI: 10.1016/j.nbd.2005.05.025

Genes

GATA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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