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Article

Adaptive morphological changes link to poor clinical outcomes by conferring echinocandin tolerance in Candida tropicalis

27 May 2025

Abstract excerpt

Antibiotic tolerance, by which susceptible bacteria survive at high bactericide doses, is known to cause treatment failure in clinical practice. However, the impact of antifungal tolerance on clinical outcomes remains poorly understood. Here, we observed that candidemia cases caused by echinocandin-tolerant Candida tropicalis exhibited higher mortality rates during caspofungin treatment by conducting a...

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PMID: 40424325
DOI: 10.1371/journal.ppat.1013220

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