Article
Structure of fibrin network of two abnormal fibrinogens with mutations in the αC domain on the human dermal microvascular endothelial cells 1.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Dec 2011
Marchi Rita, Rojas Héctor, Castillo Oscar, Kanzler Daniela
Abstract excerpt
There is evidence that clot structure can be modulated by endothelial cells, wherein the fibrinogen αC domain plays a major role in the fibrin-cell interaction. The spatial distribution of fibrin fibers from fibrinogen Caracas V and Caracas I, with heterozygous mutation in the αC domain (Aα Ser432Cys and Aα Ser466stop, respectively) on human dermal microvasculature endothelial cells (HMEC-1), was studied by laser...
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