Article
An A alpha Ser-434 to N-glycosylated Asn substitution in a dysfibrinogen, fibrinogen Caracas II, characterized by impaired fibrin gel formation.
The Journal of biological chemistry - 25 Jun 1991
Maekawa H, Yamazumi K, Muramatsu S, Kaneko M, Hirata H, Takahashi N, de Bosch N B, Carvajal Z, Ojeda A, Arocha-Piñango C L
Abstract excerpt
We have identified a unique N-glycosylated Asn substitution for a Ser at position 434 of the A alpha chain of an abnormal fibrinogen designated fibrinogen Caracas II. This dysfibrinogen was characterized by impaired fibrin monomer aggregation. Since there were 4 Thr residues immediately following...
Topics
- Amino Acids
- Asparagine
- Chromatography, High Pressure Liquid
- Cross-Linking Reagents
- Electrophoresis, Polyacrylamide Gel
- Fibrin
- Fibrinogen
- Fibrinogens, Abnormal
- Glycosylation
- Humans
- Mutation
- Oligosaccharides
- Oxidation-Reduction
- Serine