Fibrinogen Caracas V, an abnormal fibrinogen with an Aalpha 532 Ser-->Cys substitution associated with thrombosis.

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Article

Fibrinogen Caracas V, an abnormal fibrinogen with an Aalpha 532 Ser-->Cys substitution associated with thrombosis.

Thrombosis and haemostasis - 1 Aug 2000

Marchi R, Lundberg U, Grimbergen J, Koopman J, Torres A, de Bosch N B, Haverkate F, Arocha Piñango C L

Abstract excerpt

A new dysfibrinogenemia associated with thrombophilia has been identified in a Venezuelan kindred. Thrombin and Reptilase times were prolonged and the accelerating capacity of the patient's fibrin on the t-PA-induced plasminogen activation was decreased. In addition the affinity of fibrinogen for plasminogen was diminished. Permeability and electron microscopy studies revealed that the abnormal clot was made up...

Topics

Adolescent
Adult
Amino Acid Substitution
Blood Coagulation
Blood Coagulation Tests
DNA Mutational Analysis
Family Health
Female
Fibrin
Fibrinogens, Abnormal
Heterozygote
Humans
Iodine Radioisotopes

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Male

Microscopy, Electron

Middle Aged

Mutation

Source

Open in PubMed

Identifiers

PMID: 10959699

Provenance

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