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Article

On the mechanism of αC polymer formation in fibrin.

Biochemistry - 27 Mar 2012

Tsurupa Galina, Pechik Igor, Litvinov Rustem I, Hantgan Roy R, Tjandra Nico, Weisel John W, Medved Leonid

Abstract excerpt

Our previous studies revealed that the fibrinogen αC-domains undergo conformational changes and adopt a physiologically active conformation upon their self-association into αC polymers in fibrin. In the present study, we analyzed the mechanism of αC polymer formation and tested our hypothesis that self-association of the αC-domains occurs through the interaction between their N-terminal subdomains and may include...

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Identifiers

PMID: 22397628
DOI: 10.1021/bi2017848
PMCID: PMC3343699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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