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Article

Thromboelastographic phenotypes of fibrinogen and its variants: clinical and non-clinical implications.

Thrombosis research - 1 Jun 2014

Galanakis Dennis K, Neerman-Arbez Marguerite, Brennan Stephen, Rafailovich Miriam, Hyder Luke, Travlou Oreanthi, Papadakis Emmanuel, Manco-Johnson Marilyn J, Henschen Agnes, Scharrer Inge

Abstract excerpt

INTRODUCTION: Thromboelastography (TEG), a widely used clinical point of care coagulation test, is poorly understood. To investigate its fibrin determinants we used normal and variant fibrinogen isolates. MATERIALS AND METHODS: We focused mainly on the TEG maximum signal amplitude (MA), a shear modulus and clot stiffness indicator. Isolates included normal des-αC, cord, and abnormal congenital variants with amino...

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PMID: 24679643
DOI: 10.1016/j.thromres.2014.03.026

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