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Article

Effect of CIS on activity in trans of the replication initiator protein of an IncB plasmid.

Journal of bacteriology - 1 Jul 2000

Praszkier J, Murthy S, Pittard A J

Abstract excerpt

RepA, the replication initiator protein of the IncB plasmid pMU720, acts preferentially in cis. The cis activity of RepA is thought to be mediated by CIS, a 166-bp region of DNA separating the coding region of repA from the origin of replication (ori) of pMU720. To investigate the trans activity of RepA, the repA gene, without its cognate ori, was cloned on a multicopy plasmid, pSU39. The ori on which RepA acts...

Topics

DNA Helicases
DNA Replication
DNA, Bacterial
DNA-Binding Proteins
Escherichia coli
Gene Dosage
Genes, Bacterial
Models, Genetic
Mutation
Plasmids
Proteins
Replication Origin

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Trans-Activators

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Identifiers

PMID: 10869075
DOI: 10.1128/JB.182.14.3972-3980.2000
PMCID: PMC94582

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