Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional repression of the α7 nicotinic acetylcholine receptor subunit gene (CHRNA7) by activating protein-2α (AP-2α).

The Journal of biological chemistry - 9 Dec 2011

Finlay-Schultz Jessica, Canastar Andrew, Short Margaret, El Gazzar Mohamed, Coughlan Christina, Leonard Sherry

Abstract excerpt

The CHRNA7 gene, which encodes the α7 nicotinic acetylcholine receptor (α7*nAChR), has been implicated as a candidate gene in schizophrenia. Expression of the α7*nAChR mRNA and protein are reduced in multiple regions of post-mortem brain from patients diagnosed with schizophrenia. Transcriptional regulation may therefore be an important mechanism for the regulation of this gene. A 230-bp proximal promoter...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha7 Nicotinic Acetylcholine Receptor
Share to Genetic Vectors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HeLa Cells

Share to Mutagenesis, Site-Directed

Share to Receptors, Nicotinic

Share to RNA, Small Interfering

Share to Schizophrenia

Share to Transcription Factor AP-2

Source

Open in PubMed Open full text

Identifiers

PMID: 21979958
DOI: 10.1074/jbc.M111.276014
PMCID: PMC3234925

Genes

CHRNA7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional repression of the α7 nicotinic acetylcholine receptor subunit gene (CHRNA7) by activating protein-2α (AP-2α).PMID 21979958Read ↗

The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function.Semantic proximity Read ↗

Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia.Semantic proximity Read ↗

Differential regulation of alpha7 nicotinic receptor gene (CHRNA7) expression in schizophrenic smokers.Semantic proximity Read ↗

Unanswered questions in the regulation and function of the duplicated α7 nicotinic receptor gene CHRFAM7A.Semantic proximity Read ↗

A transcriptional regulatory element critical for CHRNB4 promoter activity in vivo.Semantic proximity Read ↗

Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7).Semantic proximity Read ↗

Regulation of alpha7-nicotinic receptor subunit and alpha7-like gene expression in the prefrontal cortex of patients with bipolar disorder and schizophrenia.Semantic proximity Read ↗

Neuronal nicotinic acetylcholine receptors: from the gene to the disease.Semantic proximity Read ↗

Nicotinic α5 receptor subunit mRNA expression is associated with distant 5' upstream polymorphisms.Semantic proximity Read ↗

Targeting alpha7 nicotinic acetylcholine receptors in the treatment of schizophrenia.Semantic proximity Read ↗

Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia.Semantic proximity Read ↗

Association study of a nicotinic receptor variant with schizophrenic disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.