Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK.

doi:10.1136/annrheumdis-2011-200085

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Article

Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK.

Annals of the rheumatic diseases - 1 Jan 2012

Castillejo-López Casimiro, Delgado-Vega Angélica M, Wojcik Jerome, Kozyrev Sergey V, Thavathiru Elangovan, Wu Ying-Yu, Sánchez Elena, Pöllmann David, López-Egido Juan R, Fineschi Serena, Domínguez Nicolás, Lu Rufei, James Judith A, Merrill Joan T, Kelly Jennifer A, Kaufman Kenneth M, Moser Kathy L, Gilkeson Gary, Frostegård Johan, Pons-Estel Bernardo A, D'Alfonso Sandra, Witte Torsten, Callejas José Luis, Harley John B, Gaffney Patrick M, Martin Javier, Guthridge Joel M, Alarcón-Riquelme Marta E

Abstract excerpt

OBJECTIVES: Altered signalling in B cells is a predominant feature of systemic lupus erythematosus (SLE). The genes BANK1 and BLK were recently described as associated with SLE. BANK1 codes for a B-cell-specific cytoplasmic protein involved in B-cell receptor signalling and BLK codes for an Src tyrosine kinase with important roles in B-cell development. To characterise the role of BANK1 and BLK in SLE, a genetic...

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PMID: 21978998
DOI: 10.1136/annrheumdis-2011-200085
PMCID: PMC3268679

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