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Article

BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling.

PloS one - 1 Jan 2013

Bernal-Quirós Manuel, Wu Ying-Yu, Alarcón-Riquelme Marta E, Castillejo-López Casimiro

Abstract excerpt

The B cell adaptor protein with ankyrin repeats (BANK1) and the B lymphoid tyrosine kinase (BLK) have been genetically associated with autoimmunity. The proteins of these genes interact physically and work in concert during B-cell signaling. Little is know about their interactions with other B-cell signaling molecules or their role in the process. Using yeast two hybrid (Y2H) we sought for factors that interact...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to B-Lymphocytes
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Green Fluorescent Proteins

Share to Immunoglobulin M

Share to Phospholipase C gamma

Share to src-Family Kinases

Share to Two-Hybrid System Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 23555801
DOI: 10.1371/journal.pone.0059842
PMCID: PMC3608554

Genes

BLK
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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