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Article

The BANK1 SLE-risk variants are associated with alterations in peripheral B cell signaling and development in humans.

Clinical immunology (Orlando, Fla.) - 1 Dec 2016

Dam Elizabeth M, Habib Tania, Chen Janice, Funk Andrew, Glukhova Veronika, Davis-Pickett Mel, Wei Shan, James Richard, Buckner Jane H, Cerosaletti Karen

Abstract excerpt

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the development of autoantibodies that drive disease pathogenesis. Genetic studies have associated nonsynonymous variants in the BANK1 B cell scaffolding gene with susceptibility to SLE and autoantibodies in lupus. To determine how the BANK1 SLE-risk variants contribute to the dysregulated B cell program in lupus, we performed...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Forkhead Box Protein O1

Share to Lupus Erythematosus, Systemic

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Share to Polymorphism, Single Nucleotide

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Source

Open in PubMed Open full text

Identifiers

PMID: 27816669
DOI: 10.1016/j.clim.2016.10.018
PMCID: PMC5148640

Genes

BCR
FOXO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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